With the whole transgender thing I feel to see the big issue with this gag. Winding up in bed with someone that you find repugnant is a stock gag. Granted it doesn't deserve any points from creativity, but the only way that you could possibly find this offensive is if your taking the rather extreme position that everyone is a bi-sexual in denial or something like that. Face it, MOST people are straight and not attracted to the same gender, either not getting the attraction, or being outright apalled. The obviously straight guy getting hammered out of his mind and winding up in bed with a transgender accidently, or taken advantage of by one while hammered, is funny, and for the overwhelming majority of viewers who are straight and not into that, it would be a rather gross situation. Like it or not crossdressing and so on is not something the majority of people are into. The overall situation is no differant than the standard rom com gag of some girl winding up in bed with some utterly repulsive beast of a guy after she got drug, being disgusted by it, and trying to sneak out before he wakes up and failing... and so on.
See, the only viable reason to complain here is if you are putting the transgender community on a pedestel. Your also pretty much claiming that a straight guy has no right to be repulsed if they were to find themselves in such a situation, as if to basically claim nobody has the right to be straight and to NOT like certain sex acts.
Okay, granted, I can see how a certain scene might not have worked for some people. However to decry a movie largely because it's not politically correct, especially a movie like this one, seems to be going a bit overboard.
I'll go one further, pick a sex act that you find repulsive, if your really tolerant maybe something involving feces, vor, or maybe both. You head out, get drunk, probably do some mind altering substances and wake up in the morning with a person while covered with feces and polaroids of you sticking your limbs down the throats of emaciated barnyard animals while having sex littered liberally around where you woke up, do you think your just going to go "oh gee, that's wonderful", no it's going to bloody freak you out. You can't say "that's differant, we're *only* talking about a transgender here" when no, it's really not, your turned off by what your turned off by, it doesn't matter what it is. If some really butch lesbian wakes up in frilly lingerie tied to a bed by a snoring muscle man it's a similar kind of gag since it's so disgusting and out of character for the person involved.
There is no reason why transgenders should be put up on a pedestel and prevented from being used for things like when when dealing with straight guys who frankly aren't into that, and would be disgusted to find that they were involved in such contact. There is nothing wrong with being straight.