Yes. Not regularly, but more than a few times.
No spoilers for these two - both games are over ten years old:
1) the death of Floyd the Robot in "Planetfall" (text adventure, look it up). He has been an annoying comic relief device for the entire game, but he is your only company in the abandoned complex, and he dies valiantly.
2) and the final conversation with the Overseer in "Fallout". He tells you that you saved your home from destruction by famine, but that you are too changed by your experiences to ever be allowed to return.
I won't say that I was bawling uncontrollably, but I was very affected.
I agree with the Croshaw opinion of "Red Dead Redemption" - he really likes games that are very unified experiences, and games should not always attempt to be cinematic. Sometimes, though, production values really lift a game to the next level. The final moments of the main story arc are deeply moving, and I am glad that they made the epilogue very short. The epilogue was anticlimactic, really - if it was more substantial, it would have diminished the experience of ending the major storyline.
I am betting that more people were quiet than were laughing, at the end.