Well... I been suffering from physical pain condition for almost 3 years now. And every time it gets bit worse I usually get depressed, lose my appetite, get anxiety and panic attacks, become really tired and frustrated. Specially when i take the medication and it doesn't help or has poor response, it depends on the day how well it works, sometimes not at all and sometimes it works really well.
I don't mind pain, when it is not constant. But when it has been constant for 3 years you start to seek reasons to just wake up tomorrow.