This is something that me and a couple friends have gotten into long debates over. Keep in mind, we exclude the possibilities that are available in the X-Men universe but not our own. So far the best idea that we've come up with is introducing HIV into his system, but we can't even decide if this would work because he regenerates/heals.
How would you kill Wolverine if you had to?
How would you kill Wolverine if you had to?