Great Teacher Onizuka.
Onizuka is a lazy, unambitious and pathologically irresponsible bum who has no idea what he should be doing with his life - until he pretty much just wakes up one morning and decides to become a teacher. A GREAT teacher. He eventually gets a job at a high school, where he's put in charge of a class of kids who have made it their mission to get rid of any teacher assigned to them, by any means possible. They have driven away an impressive number of teachers so far, and actually make some attempts at Onizuka's life, but since he's more street punk than teacher, he is able to win most of them over.
Together, Onizuka and his class face a variety of challenges, including the occasional student who still hates Onizuka, as well as much of the school staff who feel that Onizuka's antics belong in an asylum and not in a classroom. The series is hysterically funny, and much of the comedy comes from the over-the-top situations in which Onizuka finds himself, and his outright superhuman ability to come up with the most insane solution possible. (Towards the end of the series, he drives a motorcycle into a burning building, up several stairs, and out through a third-storey window. I won't say why.)