I love the idea of a webcomic set in a MMORPG. If it starts to get popular, you'll have fans sending in stories about funny gaming incidents, just like "Dilbert" gets stories from office workers.
For a staple character, instead of the usual idiot, how about a player with a crazy awesome computer system: 3 monitors, always has maps and monster info displayed, usually for the wrong zone. In combat he runs amazing scripts that he created... for a different character... possibly from a different game...
Finally, here's something I would love to see in a comic, and it would absolutely have to be set in a MMORPG:
The heroes discover a secret cave system, not on any of the maps (3-monitor guy double checks he's looking at the right ones). Inside are hundreds of goblin slaves, although the heroes only see a few of them, all mining. Turns out the goblins are actually players, all named "azngoldfarmrXXXX." One of them can speak English. When someone comments on his poor spelling and/or grammar, he says, "Yeah? You try type English on Chinese keyboard, smart ass!" He's been in this cave for months, mining ore and handing it over to the ogres who run the place. He has no idea there is a virtual world outside the virtual cave. The heroes rescue him. When they get outside, the light hurts his eyes - until he adjusts the brightness on his monitor. He tags along for a while. He is useless in combat, but his amazingly high mining skill comes in handy once or twice.
So there you have it; there's my idea - the reason why I just signed up to post on the forum. If you like it, please use it. If you hate it, please don't flame me. I'll cry.