Two of my own best lines:
"If God didn't want us to help each other out, then why did he put us so close together?"
"God's a comedian, who else would make a platypus?"
Some of the best advice my parents ever gave me:
"Try it." My mother was brilliant with this one.
"Politics will always piss off someone." My Father's reason fr avoiding said subject.
Other good advice I've been given:
"It's just a game."
"Give it a shot."
"Grow a pair." (for the record, I have)
"There is no convincing argument in the human mind for daylight savings time."--Dave Barry
"The worst ideas often make the best memories." --a Philosophy teacher of mine.
"Humans are strange. That's the fun of it, though."
"God's not dead. He's often shouted over, but he's not dead."
Video game lines:
"Power is not strength. Until you learn this, you will achieve nothing." Wang Jinrei from Tekken.
"Honor is not in dying for an ideal, but living to defend it."
"Enlighten me!" Initiates in C&C: Red Alert 2: Yuri's Revenge
Comics:
"I'm not psychic, but I'm not some big dumb idiot. My dad was a rocket scientist and my mom was a doctor. I admit my brother's smarter than me, but I'm not stupid. So how about you hear my thoughts on women's rights--over dinner?" Juggernaut, giving the best pick-up line ever.
"Knowledge is power. And I'm not intent on sharing." Nemesis, avoiding the typical villain monologue.