Very much so. It actually has manuscript pages only available on Nightmare difficulty after you beat the game once. I assume these are REALLY good pages, too. Plus, you'll have new insight into old scenes, to see hints and foreshadowing you didn't recognize the first time through.
And, if you have Collector's Edition, you can then playthough with the spoiler-tastic video developer's commentary. A little head of a dev will pop up in the corner and tell you about the game and scene.