So here's my two cent... what makes a game and RPG? If it is a literal translation, then it's a pretty loose definition since most games see you playing a role as it stands for ROLE playing game, I mean even in Mario Galaxy, you take the role of Mario. If you want to make this specific definition less loose, then I would suggest that a ROLE playing game sees you taking a character and making decisions that affect the story somehow, in which case both Mass Effect games definitely count as RPGs. However, games like Final Fantasy XIII wouldn't necessarily be counted as such, which many people would argue against (Final Fantasy VII would just because you could affect certain aspects of the game, like the love interest potentially).
So what about the traditional translation of an RPG? Inventory, levelling up and the like. Well, yes, I can see the arguements for and against, however, I would personally still argue that it was since you affect your character development through levelling, and you can still customise equipment, attire and you still technically have an inventory, if only an unconventional one, it's a bit like saying Fable III isn't an RPG because you don't technically level, but you do, it's just done in a different way.
In the either case, I don't think this is a clear cut arguement. Bioware made a very conventional RPG with Mass Effect 1 using tried and tested systems they previously used in games like Knights of the Old Republic, or Baldur's Gate. Thing is, these are dated and Mass Effect 2 was created to keep the game modern, fresh and innovative, and it worked. It's evolved past it's original definition of it's own genre, I mean look at how many modifications Dragon Age II is going through.
My personal opinion, however, is games that evolve in this way can't be put in one specific genre easily, why? Because they're turning into something truely unique that has come about through trial and error, to the point where categorising them just seems... wrong.
That's my view on the matter anyhoo.