Honestly, if you first came across this series, you would get confused, and ask questions like "Where IS Dr.Wily?" even though he's deader than dead after 100 years, with the main cast of the original disappeared or met their demise as well.
Well, Wily was somehow involved in X5, sort of. It's hard to explain, because the plot is, by all accounts, confusing/horrible by the time the third game rolled around. You definitely don't play this for the meat of the story, or shouldn't. Also i'm glad it WON'T be full 3D, because the 7th game was a complete disaster.
Hopefully though it'll get us to make the jump from the X series to the Elf Wars, which means even more things to shoot at. That's if this MMO even makes it off the ground and becomes popular that is.