Most dreaded sounds in gaming.

[Canadamus Prime]

That squishy noise the Protozoid Slimers made in Duke Nukem 3D. God I hated those things.

 

[Amyler]

For me, the witch's theme was always more intimidating than the tanks. Not for what was coming, but just because it was so unsettling.


Another painful song is the Black Hole CO Super Power from Advance Wars 2. It's a very big military level "SCREW YOU" to the player.


For individual sound effects (That haven't been mentioned, most of mine are already up here) I'd propably go for the crying sound from baby Mario in Yoshi's island (SNES version, haven't played the other) for its oh crap and annoyance factors, and the guitar's sounds as you fail a song in Guitar Hero.

 

[Vrex360]

That all too familiar sound of a beam rifle firing in Halo 2. When I am playing as the Masterchief and I am surrounded by Marines I quickly realize that the only thing that could have fired that would have been the dreaded Jackal Sniper and that therefore I must find cover and begin what amounts to a deadly game of whack-a-mole as I peek above cover and pray that I can shoot them before they shoot me.

 

[Jezzascmezza]

SCCRRCHHZZKGHKK-

The sound your 360 makes for the first and last time after moving the console with a spinning disc inside.
Rest in peace, Crackdown...

 

[Cowabungaa]

First of all:
HOLY SHIT THAT SCREAM!!!!!
OoT ReDeads are nothing compared to those.


Second place goes to the dreaded Click of Death in Counterstrike: Source. Or well, pretty much every shooter. You're in the middle of a gunfight when all of a sudden "chinkchinkchink" OH SHI- And you're dead.

 

[ECasThat]

What about anything SHODAN says?

 

[amucha98]

.

 

[not_the_dm]

"Strategic launch detected." *beep* *beep* *beep* *beep* *beep*

When your strategic defense silo is only at 62% construction. Or less...

 

[Dr. Paine]

This. [http://www.youtube.com/watch?v=jsaS2bf5w6E]

 

[Lem0nade Inlay]

The dreaded series of chords that accompany a hunter/smoker/boomer/witch in Left 4 Dead.
And the "mmmblughh" of a boomer

Also:
"TACTICAL NUKE INCOMING!!! IT'S OVER!!"

 

[Withall]

The heavies from Darkest of Days. Their mini-guns sounds like the GAU-8 Avenger. EXACTLY like them. I suppose the sound their weapons make sounds somewhat like a top-level predator that once hunted us back in the day, somewhere.

Or maybe it's just me anticipating a hot lead perforation within a few seconds that makes me go "ohshitIdontwannadie", and makes me scared.

 

[captaincabbage]

Mario's invincibility star song, for the goombas that has to be the most dreaded sound in the world XD

 

[Deadman Walkin]

That magical buzz your computer makes as it freezes because it can't handle that awesome game you are playing Kills me a bit inside every time

 

[yossarian787]

"There you are."
-The cutest, deadliest turret ever, from portal


"Nu-nu-nuclear launch detected."
-starcraft or starcraft 2, right before you lose your base.

 

[CptShiv]

"ENEMY AC-130 ABOVE!!!"

 

[sketch_zeppelin]

I don't know why but the hiss of the Cacodemon from Doom always freezes my blood.

 

[rosac]

The sound of a chainsaw starting up in RE4, quickly followed by this:

Meh shi-

gamenoises of leons head leaving his body in an extremely gory manner.)

 

[nightangel346]

anytime there are bugs in video games... spiders to be exact, freaks me out more than anything else

 

[MattyDienhoff]

The bloodsucker roar in S.T.A.L.K.E.R.

 

[IxionIndustries]

*Tink tink tinktinktinktink*

Awww shiiiiiii-

*BOOOOM*