World of Warcraft, pretty much every boss says something epic or amusing. My favourites are:
Anything vishas says. (sm gy)
YES, I am a GOD! (dude in mgt)
The living are here! (not a boss but real stratholme)
Usurpers! Gnomeregan is mine!!! (the guy in gnomer)
The thing highlord sylvanas says just before pwning everyone at the wrathgate. (wrathgate achievement cutscene)
The best part about being dead is. After all, what's the worst thing that can happen? (female undead emote)
The gnome getting killed by Jaraxxis. (toc)
Rawk trinkets, yes pretty trinkets, rawk powerful, rawk, power in trinkets. (talon king ikiss... wording may not be exact but its close enough for government work)
Well there are thousands more 1 liners.
And of course I know it isnt from a game but, "The man in black fled across the dezert and the gunslinger followed."