Eh, I played the original Prototype and it was "okay" at best for me. The story was downright shit, though you wouldn't play a game like Prototype for the story. The gameplay felt average for me, nothing really surprising, but I will admit it was fun to go crazy every now and again and eat up everyone you saw.
Overall, it was "average" to me. Though since Activision is publishing the game, I'm not going to buy it anyway (I've stated why I won't buy Activision products before), but it will be interesting to see how Prototype 2 (if this is Prototype 2) will improve on the formula.
And since the comparison is always made for some reason, I liked InFamous more since it felt more focused and the story actually had some sanity.