The world is basically a worse version of the one we have today, a worse case scenario, highly implausible, maybe. The story is set just a few years into the future 5 or 6, 10 at the most. The American recession never got better, it just kept plummeting downward.
Money became all important and the rich turned their financial power into a political one, aligning themselves with the federal government, while the poor were left to rot. Faced with little options many people turned to crime, in turn declaring their loyalty to the charasmatic crime lords, who offered protection and shelter in exchange for "favors". Drug trades, robberies, prostitution has been high for years.
Cities like Vegas swiftly became overrun by the mafia that have always been hidden underground, it's a cesspool, but it's a place where anyone can get and do whatever they want.
Washington became overrun with riots and death threats, the military and the secret service tried their best but they were outnumbered by the desperate, and the insane.
Now all the political power rests in New York, now a sharply divided city. The politicians and the rich and upper middle class still live in relative comfort and safety around Time Square. But the rest of NY has become a battle ground for the various crime lords and drug dealers waging a war for control.
With military power moved mostly to America, a new terroist cell has silently infiltrated. They've only made small attacks for now, but most figure it's a matter of time before they strike big, in an attack that demonstrates their true power. Many people actually hope for an event like that, a devastating attack that would unite the country once more.
With so many sick and dying, the medical industry has entered a huge boon, more and more funding has been placed in the corporation Syntho-cure (name pending) and their fabled Project Evolution (name also pending). Project Evolution began back in the seventies under the name Project New Blood (you guessed it, name pending) New blood took "volunteers" and administered them with injections that were suspected to create a stronger, better human.
New Blood was recognized as a failure and "officially" shut down in 88 after it yielded no results and many of the subjects were showing signs of a strong, deadly cancerous disease. The disease attacked slowly but within 20 years more than 70 percent of the subjects died. The researchers discovered that though the subjects were slowly dying, the disease was also present in their children, though it was changed somehow. Many proposals were made to reopen New Blood, but they were all rejected until Syntho-cure made a shrewd move and bought out the majority of America's various medical companies. This gave them access to the records of New Blood.
Ufortunately many of the patient records were lost during the attack on September 11. (I may change this if it proves too offensive.) Gene charts were lost, save for a few. The hero was one of those few, and in his mid twenties, it was discovered that he was afflicted with the same cancerous disease.
He lived with the disease for a while, so for a few years he's been reassured in the knowledge that his death will come quickly. He's also never really been exposed to the crime element that much. He spent most of his life in New Hampshire, a state which is still relatively safe. Only recently did he move to NY, and when he did he moved to Queens, again a relatively safe place. He, like all other citizens knows about the criminals and the lingering terror threat, but it's always seemed far away, until he gets super powers and is thrust into the middle of it.