The only thing I particularly see as ominous is the omission of Donald Blake,which I suppose they traded for Thor's lack of dignity. The cup thing is hilarious, don't get me wrong, but it seems that they traded the serious movie for a action/comedy/drama/romance that really only worked in Spider-man.
And that was fine, for Spider-Man because Peter Parker was a nerd, and there's nothing the world likes more than to pick on nerds. But most of the other Marvel characters are actually rather serious, especially Thor, Hulk, and Captain America. So I'm sure Thor will do well, but fans will probably shun it like the Star Wars prequels.