Two words: THE BOYS! By Preacher creator Garth Ennis!
Anyone who doesn't like superheroes will enjoy The Boys. The comic is set in an alternative universe where WW2 - era scientists came up with a chemical that gives people superpowers. 60 years later, superheroes are running rampant, being worshipped like rock stars while the government covers up their often insanely destructive antics, making them look like the glorious heroes of the comic books.
That's pretty much ALL the government can do - the superheroes, with their super strength and laser vision and whatnot, are impervious to any kind of law enforcement and just do whatever they want at all times. This is where The Boys come in: A group of axe-crazy misfits who live only to kick superhero ass! They are constantly keeping an eye on every superhero out there, and whenever a group of superheroes step too far out of line, The Boys grab their baseball bats and crowbars and administer a well-deserved, epic beating!
Alternatively, if your friend just wants to avoid superheroes altogether, I would recommend Transmetropolitan by Warren Ellis (for the reasons stated by Neonbob), The League of Extraordinary Gentlemen by Alan Moore (especially to people who likes steampunk)...
... or, if I may suggest a classic: Popeye!
Yes, I know those cheap 1960s cartoons and comics familiar to most modern audiences aren't that entertaining - but the original newspaper strips drawn by Elzie Crisler Segar from 1929 until his death in 1938, are still considered to be among the finest comics of all time. Forgotten for decades, the original strips are now being re-published by Fantagraphics. For someone who is unfamiliar with comics, the original Popeye strips are WELL worth checking out!
