I have tried ESDF but then I dropped it. It's not bad, per se, but I kept putting my fingers on WASD by accident and going back instead of left. Sure, I got in towards the end but on the other hand, I didn't find the extra keys around that useful. I can't remember what I played at the time but it was something with more keys available, yet even then the expanded number of availabilities was an overkill.
I might try it again if I find another game that has even more keys, though. I'm not against the idea, but the getting used to wasn't worth it the payoff from what I saw.
As for others, I've seen some people use some rather bizarre setups. There was a (short lived) trend around where I was to try and play with strange keybindings. The unifying theme was "If somebody tries to play with your config, they mush be unable to". I can't explain it better than that. Here is a sample key configuration for an FPS:
- Left-click - shoot (that's pretty much the only sensible one)
- Right-click - jump (alternatives: reload, crouch)
- Space - forward
- Z/X/C (one) - left
- C/V/B (one) - right
- X/C/V (one of the buttons between the two above) - crouch
- Shift - back
- Ctrl - reload
That's just ONE of the setups. And that's a sample, I made it on the fly since I can't remember any of them in full, but some of the keys do come from a real one, the other ones I filled up with things that made sense. In context, that is. Thing is - the movement keys were pretty much never in one place - left and right would be but back/forward wouldn't be with them and would be together, either. It wasn't uncommon to have left and right one key apart (e.g., X and V) and have the button between them be used for something significant - in the above example, C would be crouch but it might also be alternative fire or jump or something else you would be using often. The mouse would be used for some really odd stuff, like jump/crouch/walk maybe even movement, but also possibly flashlight or something else that you think shouldn't be there, extra buttons could also be utilised for some rarer-used buttons but ones that you still need few time in a play session - the fire button was usually left there but could be swapped to right-click. Sometimes it might be elsewhere, though, like space, for example. The rest of the buttons would be in reach, since the bindings wouldn't really be scattered randomly - as you can see above, your left hand would mainly be laying on the left side of the space bar, so the rest of the buttons would be in that area. Do bear in mind this is just one style - you could tailor it around your hand being around the J key or around the Y key or whatever else. This wouldn't even involve just shifting the above config to be up and right a bit, but everything could be different - walk left/right with Y/U, reload with 7, crouch with Alt, etc, etc.