My major one atm is Fifa 11, I'm playing the demo to death and need to get my fix of this game... Only 10 days to go.
I'd say Bioshock: Infinite, but I've not long finished Bioshock 2 so there's still replay value in that. I've not played Fallout 3 yet, somehow, so I doubt I'll be touching New Vegas til after I've got round to it but I am really looking forward to Arkham City, Assassin's Creed: Brotherhood, Dead Rising 2 and Crysis 2.
I've basically stopped paying attention to game release days as I've got older though, seeing as I have to pay for them myself now... And can't afford release day prices on a student salary.