Honestly, get used to editing. Remember; every hour of talking is two hours of editing. Remove the umms, remove dead air. Have a list of topics, but don't feel like you MUST stick to them if it's going off topic but interesting. A good rule of thumb; listen to it again when you're done. Anything that isn't funny? Anything that isn't intelligent? Cut it.
Be constant. It doesn't matter if you do every week, every two weeks, every month, as long as you keep to the schedule.
May as well be honest:
If it's just you and your buddies making a podcast about gaming "stuff", don't bother. They are literally a dime per dozen. Get an angle. You're coming in late to the podcast scene, and the general nerd stuff is covered by everyone. If you don't have something unique to add, you may as well try getting into someone else's podcast.
If you think you're going to get rich off this, don't bother. Most podcasts are actively loosing money, and even the big ones don't make huge amounts of money (how big? Rooster Teeth, the 11th largest YouTube channel, barely covers the costs).
Most podcasts don't last beyond three months. Something to keep in mind. Make sure you have 10 weeks worth of topics before you start. If you can't think of ten topics, then you may as well call it.
Have you got a decent microphone? If it's a chore to listen to, no one will listen to it. There are literally ten others who are doing it right. You can't afford to be shit.
Advertise. No, just a Facebook page won't do. You need a Twitter. A website. An email. You need to start contacting other podcasts and getting onto them and then ask if some of them will do the same. You need to go to events. Those little business cards are great. Have a local friendly shop? Ask if you can leave some leaflets of your podcast there.
Get a good title. Something snappy. If the title is long-winded or just shit, no one will care. If it's not to the point, no one will know what the hell it is about.
Get a good description. Here is one for Fear the Boot; "A podcast about tabletop roleplaying and a little bit more".
Get artwork. No, not some paint made piece of crap. Get an actual artist to put together a podcast art cover. This is what people will judge you on when they look at your podcast.
Don't be wrong. If you're setting yourself up to be a factual podcast, be right on the facts.