If I was on my other computer, I could give you a real list, but here's a shortened one.
A Life Well Wasted - See "This American Life" but center each episode about games.
TalkRadar - A toned down GameSpy Debriefings where they actually talk about games.
GameSpy Debriefings - Stupidly and offensively funny. Great listening.
Idle Thumbs - Although Idle Thumbs ended, it's amazing backlog, while dated, is some of the greatest podcasts of all time.
Geekbox - A show about general geek culture. It's pretty good but very nerdy.
This American Life - It's the TAL show. You probably know what it is. It's fictional stories that are related to a common theme each episode. It's amazing.