Ahem... if you play GTA:4 while drunk, the actual drink driving sections of the game start to make so much sense. You still suck at driving, obviously - it just makes more sense. It's like a metaphor for life, or something.
Back in January me and a small crate of Wychwood ale plowed through the DLC's for GTA:4 (FYI, lot's of anachronism going on here, FOB, RESPECT, Snoop DO-double G.)I remember being utterly entranced by the club management mission's you can do in Gay Tony. I think you have to be drunk to enjoy those.
People have mentioned guitar hero and rock band, great fun to play while drunk. If you have somebody drip feeding you alcohol while you rattle at the keys, all the better, because it's hard to hold a beer while playing.