Perhaps actually telling an example joke here would help.
"They say that kids are bieng turned into murderers by hyper-violent computer games like Grand Theft Auto and such, i have but one counter argument to this and it is to look at me for 5 seconds; the living embodiment of weakness.
My arms are noodle thin - Madonna actually beat me art arm-wrestling,
I'm so pale that Micheal Jackson once asked me for skin samples.
And if you are seriously telling me that playing [prototype] - a game in which you devour random civilians to regain health, has twisted me psycologically to become the next Hannibal Lecter, then please take note:
I have become so physically weak, and incapable of murder, through extended 4 hour raids on World of Warcraft, that i now require both hands to click my PEZ dispenser..."
That kind of thing uses gaming as a topic but does not require in-jokes to an actual game, that should go down fine, surley?
Comment on this and i'll use a more game centered joke and see what you think.