I should've checked before voting. I thought this was for what system people plan to get the game for, not which one people suggest. Oh well.
I vote 360 because it's the only console I own that will have Prototype and because I really am not a fan of the PS3 controller (it's too damn light, I feel like I'm at risk of breaking the damn thing every time I pick one up at a friends house. that and the shoulder buttons don't work as well).
If you do want a superhero/villain game for the PS3 I'd suggest Infamous, its sony exclusive and looked pretty tight. But as far as I'm concerned, Prototype is the closest I'm ever going to get to a next-gen sequel to Incredible Hulk Ultimate Destruction (one of my favorite games from the last generation) so I'm going to get it, and enjoy the fun of leaping across the city leaving destruction in my wake.