I was once a die-hard Arrow Key user. If a game required use of WASD, I'd remap the buttons... all of them, if need be.
Then I stopped playing MMOs... EQ and WoW helped drive in the concept of using many keys at once, but I'd either used the Arrow Keys, or eventually the Mouselook Movement options (Hold Right Button to turn + Hold Left Button to run) to move around in the world, leaving my left hand to dance about and play Whack-A-Mole with my hotkey activations.
Then I leave that all behind (money issues, and easier to give up the monthly fees for cheaper bargain box games) and was thust into the world of WASD movement... and haven't looked back, since.
But, if you're looking for options for "unique" control options, I was a total convert to Belkin's Nostromo N52 after I tried it out once. D-Pad thumb movement under a big red thumb trigger button, keyboard-style finger layout, index finger mousewheel placement, and a thumb "slap pad" button (think: "spacebar" placement, but placed perfectly under your thumb)... all completely programmable and customizable with 3 possible Modes to flip between on the fly. Add in my ancient MX500 mouse (when this thing finally craps out, I'm going to be lost), and I had enough buttons avalable that I only ever had to touch my keyboard to type in chat.
Sadly, mine has seen better days after years of use before my retirement from online play, and I heard that they'd stopped production a year or two back.
EDIT: Upon looking, it seems that Razer has picked up the Nostromo product name and is continuing production. ( http://www.amazon.com/gp/product/B004AM5RB6/ ) If I get pulled in to SW:TOR, I may have to look at my budget about replacing my old Belkin.