I say yes, but...there are two amendments I have for that.
First, play with a group of friends who won't take the game too seriously. There's no bigger kill-joy than a rules nazi...especially considering the multitude of rules D&D is based on.
Secondly (and this is almost as big as the first point), you might not want to invest too much into 4th edition. It strikes me as a effort to compete with WoW, which has dumbed the system down a bit...and turned it into a miniatures-reliant game. I liked 3.5 better, despite the numerous flaws it had.
Finally, as an anecdote, my group has always been pretty evil. While I was DMing, the PCs stumbled upon a hoard of gems (among other things), and sold them off to a vendor, from whom they got roughly a quarter of the gems' worth. Not realizing they had been ripped off, they went about their business, but by the next day, talk around town was that some adventurers had been chinsed out of money to help rebuild the town. Furious, they went back to the vendor (a jeweller, as it were), and quickly killed him, drafted fake writs of ownership, and took up the business as their own. They reduced the prices by a third, finding that they still turned a profit, and the assassin of the group began systematically killing off those who questioned their ownership of the store, and their chief competitors in town (this was a trade hub, so there were multiple jewellers in town). The paladin, who by now had become a blackguard (i.e. lost his holy...ness), ran the store front, whilst the wizard busied herself with keeping up appearances, and the rogue (not to be confused with the assassin) dealt with security issues, and trade partners. This life constituted much of the campaign, but eventually they were discoved to be mass-murderers, and were run out of town (barely surviving), with a paladin who had previously looked up to them serving as a new recurring villain.
While this is by no means a funny anecdote, I hope it served to show the system's versatility. It's not all about hacking down monsters.