Depends on the character. Whiskey Rose is the best companion perk in the game for a melee or unarmed character, imo. With enough survival, you gain 21 DT by downing a whiskey, wasteland tequila, and a large wasteland tequila. Yeah, those all stack. Cass was invaluable to my first character, since I was light armored and unarmed. Two Deathclaws instead of the one I was after? Time to get drunk.
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