Red Dead Rastafarian
Like Red Dead Redemption, only set in East Africa, and featuring a group of pot-smoking Jamaican rapists riding around deserts and scrubland in present day Somalia/Eritrea/Ethiopia in their pilgrimage to find Haile Selassie I of Ethiopia.
The game features a new peripheral similar to the WiiPulseChecker thing called the Ganjameter which measures how high you are and changes the game/gives you powerups/downs accordingly. Also, it's an open ended game world because of this, so you can get really high and find an antelope that looks like Haile Selassie to nominate as your living god, for example.