Not really. I'm kinda immune to getting blackout-drunk. A high tolerance for alcohol mixed with a weak stomach lining means that I can't drink enough of the weak stuff to get me that drunk, and too much of the strong stuff will burn a hole through my stomach before it burns a hole through my brain.
So far the worst thing I've done was not sleep with someone (overzealous internal defense mechanism) because it *might* have resulted in some very minor annoyances later on. In retrospect, I should have hit that because the worst could have been pissing off a person I didn't really care about in the first place. Hardly counts as a regret, about as much as going to a new, slightly disappointing, pizza place instead of the old favorite.
So far the worst thing I've done was not sleep with someone (overzealous internal defense mechanism) because it *might* have resulted in some very minor annoyances later on. In retrospect, I should have hit that because the worst could have been pissing off a person I didn't really care about in the first place. Hardly counts as a regret, about as much as going to a new, slightly disappointing, pizza place instead of the old favorite.