They should make another one. At some point there's a slightest chance I'll like one again. Averages, bitches. (though I haven't played Revelations yet, and the demo seemed alright).
What I would like to see though is Outbreak on PC, a combo of 1 and 2, as well as enough content for a third in there, as one game, with dedicated servers and Lan options.
Also, more focus on the closed in, locked down, horror aspect. I do not care if it's scary, I don't mind if it's not zombies, just give me something horror themed and new (for the series) would be nice. I don't care if it's werewolves, vampires, mummies, trees, moving dolls, laughing mounted deer heads, ZOMBIE BEARS, what ev. They did zombies, rather well I think, they did Bio-Weapons, they did Parasites and I think Dead Space did it better, they tried trolls and insects, let's keep the wheel turning and just go with the next thing.
However if they do Dinosaurs I will either be so very happy, or I will hate them for it not being a new Dino Crisis game, though if they throw in Regina I can't really care too much what the name of the game is.