Setting is only one of two of the main aspects of that RPG that really changes things up // The other being whether or not you are playing a Hero or Villain character // From my own personal experience playing a Villain opens up a whole new world
The example I can give you is I was playing an Aberrant RPG, set in this world, where we got to play Heroes as well as each other Nemesis. Switching from one character to the other was like switching to a totally different game. The rules changed. How we interacted with NPCs changed and the world, to a larger extent, change.
But setting is also one of the reasons I don't play D&D as most GM's cant come up with a world that is not just like every other D& fantasy world that you have played before.
At the moment my favorite setting is the Warhammer 40K universe
-M
The example I can give you is I was playing an Aberrant RPG, set in this world, where we got to play Heroes as well as each other Nemesis. Switching from one character to the other was like switching to a totally different game. The rules changed. How we interacted with NPCs changed and the world, to a larger extent, change.
But setting is also one of the reasons I don't play D&D as most GM's cant come up with a world that is not just like every other D& fantasy world that you have played before.
At the moment my favorite setting is the Warhammer 40K universe
-M