I've really been excited for Starcraft 2 for a while, Diablo 3 looks like it might be good. I'm interested in Bioshock 2, I would like to see where it fits in with the story from the first game. Assassin's Creed 2 I might look into because I liked the first game, hopefully there will be more to it than there was in the first. Now after finding out that there is a second No More Heroes game coming out I'm really looking forward to that as well.
It would be nice to see a new Zelda game for the Wii, as well as Call of Duty: Modern Warfare 2. I would also like to see a Gears of War 3 but I can only hope the chainsaw is like it was in the first game, not so much of a god weapon.
EDIT
Something else I would love to see is for Megaman X9(if they make it) get the Megaman 9 treatment and is made as a 16-bit style game that sticks to the SNES style of the first three games.