You mean Area of Impact?
In that case, better grab yourself a science book.
First you need to work out what you're shooting (projectiles, lasers, whatever) and the diameter of that (this is very important to some later calculations).
Then the speed at which your projectile is traveling.
Then if there is any resistance to your traveling projectile (like a gravitational pull from a nearby stellar object and if you want to penetrate several atmospheric layers).
After that, what is it that you are hitting (metal, dirt, water, flesh) and the density of that abject.
And if you want to know the area affected by your shot, you'll need to know how big the projectile is, the substance from which it's made and if it's explosive or not.
I probably missed a few things too, since I'm not a true scientist, but this should get you pretty far.