Vampire: The Masquerade - Bloodlines!
It required some fiddling to get it to work, but my goodness, am I in love with this game. The music is great, the voice acting is great (for the most part), the dialogue is great, the atmosphere is amazing.
Everything about it is great, as far as I am concerned... except for the combat. It is a little bit clunky, and boss fights required some serious cheesing in order for me to survive, but maybe that is because I am playing as a squishy Tremere vampire.
But yes. It is wonderful stuff. I would easily place it in a list of "best RPGs ever made".