Richard A. Kiernan said:
Weapon-wise, I imagine that electromagnetic guns, like coilguns or railguns firing the equivalent of canister shot, would be supplemented by missiles. Somehow, I don't imagine nuclear weapons being especially common, simply because the missile would have to get within one kilometre to really do any damage besides radiation damage. Lasers and plasma weapons seem more of the territory of soft SF.
Lasers are really dependent on technology, specifically on how advanced your power technology is. Railguns/coilguns are as well, but they are a bit simpler and have lower requirements in comparison. In theory though, lasers really are a good weapon for space-combat if you can generate the raw power to make one lethal to starships. They will always travel faster than any railgun/coilgun slug and, in theory, could draw power directly from the ship's reactors, negating the need for ammunition.
As for nukes... yeah, traditional nukes are not ideal weapons for space-combat. A missile with a fusion warhead could do a lot of damage, but it would actually require a direct hit, which makes it very vulnerable to point-defense interdiction. Hellbore-type weapons are another matter entirely though. Hellbores actually make nuclear weapons viable in space. The basic idea behind it is that you detonate a nuke, trap the resulting fusion reaction in some form of magnetic field, and then direct it at the enemy... you take all that energy, all that heat and radiation, and you focus it all in the same direction, instead of having it scatter everywhere like normal nukes. There are a lot of different variations though. This type of weapon has popped up in quite a few sci-fi settings.
I know in the Honor Harrington books, the standard anti-ship missile uses a fusion bomb to power a shotgun blast of x-ray lasers that rip the enemy ship to pieces from about 200,000-300,000 kilometers out. That way a direct hit is not required and the enemy point-defense has less time to intercept the missile.
If you haven't read the Honor Harrington books, do so

They are a good series and take a more realistic stance on space combat. The first two volumes are actually up, in full, for free on the publisher's site. You can't beat free. http://www.baen.com/library/067157793x/067157793x.htm
Plasma could work, in theory, but its tricky. Well, for space combat plasma really isn't desirable. You could do as much or more damage with kinetic weapons or lasers in a much simpler fashion. For planetary operations, plasma guns could work. I forget where I saw it... but the plasma guns in this one setting were kind of neat. Basically, each blast of plasma was encased in this plastic-like material as it left the weapon. This kept the gasses concentrated and on target, and once contact was made, the plastic stuff ruptures and the plasma is released to burn the ever-loving hell out of the target. If you could make them work, plasma weapons would be great for anti-infantry work, or for light vehicles. Zero penetrating power, but that kinda heat should just melt unarmored and lightly armored stuff.