This
"The super science holy grail Connors and others are seeking on behalf of Osborn is the ability to successfully cross animal and human DNA, and while Connors can pull it off, he can't stabilize it - hence The Lizard. Peter, on the other hand, was able to absorb spider traits without turning into a Spider which, in the film, is never adequately explained. But if Peter is carrying the stabilizing agent in his own blood, that not only explains the powers but also gives cause for Osborn etc. to chase him down in the sequels."
and this
"Spencer Smythe is a scientist contracted by J. Jonah Jameson to build remote controlled anti-Spidey robots called "Spider-Slayers." Eventually Spencer got his ticket punched, but his son Alastair picked up the mantle and kept the robot-making dream alive, eventually mutating himself into a "human" Spider-Slayer."
was basiclly done in the movie tie-in game. Would be funny if they did it in the movie sequel