I finally finished Dorohedoro after owning the full series for like 3 years. I'd tried it before, but around the halfway point the plot gets super complicated and I always got confused. But I'm glad I managed this time, because it certainly has a proper ending, and there's simply nothing like it. It's one of the most bizarre, visually repulsive and grotesque, yet creative, wholesome and sweetest things I've ever read. There are parts in this manga that give Berserk a run for its money in terms of graphic content: horrific violence, unspeakable body horror, mutilation, and imagery that, if I were to see them as a child, I'm pretty sure would give me nightmares. The entire aesthetic is ridden with filth, grime, sweat and blood, and the setting is truly one of the crapsackiest, most nightmarish places in all of fiction. The story and concepts depict a world of endless suffering, monstrous inequality, and utter despair without hope of things getting better.
All of the above description would point to a series that would make you want to dig straight down in Minecraft, but it's anything but. It's one of the goofiest, most unapologetically upbeat and gleeful series I've read in a long time. It absolutely revels in its own absurdity with insane visual creativity. It's almost Axe Cop level at times with how nonsensical it is, but its level of commitment makes you just accept it. This guy's got a turkey for a head, his name is Turkey! There's a cat wearing a gimp mask who can bring people back to life! There's a guy who's half human, half toothpaste tube who can create replicas of people! There's a horrific bird creature named Store who chops people up, and there's a knife made from its feathers that's called the Store Knife, and it's the most powerful weapon in the universe! This kind of gleeful nonsense and upbeat tone combined with the just horrific visuals make it one of the most tonally unique things I've ever read.
The uniqueness extends to the characters, who are all fun and likeable. One special thing about the series is the near total absence of an explicit villain or antagonist. The cast are on opposing sides with differing agendas, but no one is depicted as outright evil or in the wrong. En is a ruthless crime boss ruling with an iron fist, but he genuinely cares for his underlings. Caiman, the closest thing to a series protagonist, is goofy and fun, but he's also a serial killer who chops up people without remorse. Shin and Noi, the most charming duo in the series, and psychotic mob enforcers who revel in violence, yet they also deeply care for each other and aren't sadistic or mean-spirited. Chidaruma, who's basically the Satan of this world, frequently just hangs around and is pretty chummy all around.
The story is probably where the series stumbles the most. Not because it's badly written, it's actually very interesting and engaging all the way through. It's just that it gets a bit too convoluted for its own good after a certain point, and spends a considerable amount of time explaining itself and its mechanics. The core of the series being a mystery (Who or what is Caiman?) does carry all the way through, but it frequently gets sidetracked with side characters and plots that get kind of muddled about what their point is. Some answers to the mystery could have come much earlier, because the series feels it's kind of looking for a point after a vital plot development (En's death). But those answers also often just spawn more questions and only convolute things more (Caiman is Aikawa, but he's also Ai Coleman, but he's also the boss of the Cross-Eyes, and the man inside him is Risu, who's also Curse, who's some sort of living magical spell or a second identity or a sort of daemonic possession and oh no I've gone cross-eyed haha get it?). What also kind of cheapens the ending is no major character dies, which feels a bit too easy for a story of this type. The series mostly manages to create legitimate tension in a world where resurrection is always on the table, and people can even survive as severed heads, but that element not coming into play at the end feels a bit too soft.
Still, it's an excellent series and well worth your time. 8/10.