Well, the weapon skills are fairly useless if you don't use VATS. The increase in damage is so marginal it's not worth it. Of course you can say "Hey, if you want your RPG-Stats to reflect in the game, play it RPG-Style" - however Deus Ex already showed us ages ago how stats can be linked with third person gameplay.Grampy_bone said:Saying the skills don't matter or show no return in Fallout 3 is also false.
Medicine is not worth one point considering you'll have enough drugs early on in the game to supply big hospitals with it, especially since stims don't have any side effect or limitation whatsoever.
Science and Lockpicking is completly unrelated to the skills. You just need a meet the n*25 steps to play the minigame, every point off is factually wasted. Same with speech and while the exact numbers aren't shown I suspect them to be be the same.
While it's true the Fallout 2 skill tree was cluttered and needed a clean up, I never had too much skill points in them contrary to F3, where the only skills actually useful are already maxed out early on. The stats however are even worse. Considering you start with a balanced build, you have to take the stat perk 4 times and find the stupid bobble head to max it, yet the gain is practically nonexistent.