I'm assuming we're talking about main characters, and not the bad guy whom everybody should hate for moral reasons from the get-go?
Lightning. She was nothing but a whiny, snooty, bossy ***** who got all up on poor Snow's grill for no fucking reason.
I'm sure there are more, but that's one off the top of my head.
Oh, and Marcus and Dom from Gears of War when I realized that humanity was the invading army. So you kill the entire planet, all the locusts and original fauna that were infected by immulsion, but fuck them, because they totally don't have families and lives and societies of their o-OH, WAIT, they totally did before the COCKS came in and roflstomp'd the planet with orbital bombardments.
And even when we are faced with this reality, it's never fucking touched upon. Oh, no, it's all about Marcus and Delta. "That's for Dom, and every else you've killed you *****."
Really, Marcus? Because the Queen Locust DIDN'T FUCKING KILL DOM, that was the LAMBANT, a.k.a. THE ENEMY THAT BOTH OF YOU HAD IN COMMON, YOU FUCK! Actually, no, it wasn't even them, Dom just chose to be fucking stupid and hopped in a car and suicided, rather than, I don't know, picking up his teammates and driving away like he did in the cutscene? And the Locust Queen this whole damn time was just trying to get his dad to find a cure for his people, but nooooo, fuck them because they aren't human, Manifest Destiny and all that shit.