To me, the plot of "Transcendence" (at least, according to the plot summary off of Wikipedia) isn't a neo-Luddite rant against technology (with the R.I.F.T. always being portrayed as evil and unsympathetic), with the narrative arc focussing on Johnny Depp's scientist first coming to grips with becoming a transcendent AI, then trying to use his AI powers to create a Utopia, followed by only descending to villainy when R.I.F.T. (and a now paranoid FBI) pushes him and his followers over the edge, only pulling redeeming himself by shutting himself down - effectively, it's only anti-technology in a "Frankenstein's Monster" sort of way - yes the Monster is literally a stitched-together undead "abomination", and does scare the hell out of the locals, but the Monster doesn't actually DO anything bad until the villagers start chasing after him with torches and pitchforks. The message isn't "science is bad", or even "transhumanism is bad" - it's only bad because the superstitious yahoos thinks that it's bad, those who think it's good retaliate, and they do a whole self-fulfilling prophecy shtick in the process.
That said, there are REALLY fucking dumb things with this movie that don't excuse this ambiguous plot (the fact it's so ambiguous people COULD mistake it as a straight, anti-tech film in the first place indicates just how epicly it failed in saying the opposite).
First, R.I.F.T. should've been better characterized no matter what - if the point was them having legitimate anti-transhumanist arguments, they should be structured with actual anti-transhumanist arguments like a religious flock who don't want an AI potentially usurping powers belonging to God's domain, or those who think singularity would essentially mean the extinction of mankind. Hell, they could've been better if they were supposedly genre-savvy pop-culture geeks who "knew" any AI with the power to manipulate events to exterminate all inferior humans in the vicinity would do so (like, they actually LITERALLY cite the motivations and methods of Skynet, HAL-9000, etc.), it still would be more grounded and realistic than just saying Depp's project is an "abomination", and calling it a day.
And if the point was that they're just loony, neo-Luddite terrorists, they should've had the neo-Luddite factor taken up to eleven (i.e. no "radioactive bullets" and no hacker technology - just straight up guns, pitchforks and torches), with no sympathetic motivations or moments to confuse them as even remotely good guys.
Second; yeah, the whole "Playing God" thing is such a damned cliche that, if it tries to sneak its way into a supposedly "serious" movie, it should be dragged out behind the shed, shot in the skull, and then hacked with an axe before being spread in the mulch. Again, it seemed to be the point was Depp's character WASN'T trying to play God in the first place (or at the very least, tried to be a more benevolent God before the dickwad humans forced him to take the "fire-and-brimstone" approach), that scene obviously doesn't help either his or the movie's case.
Third, the whole "only 100 people show up to a world-shattering event" thing definitely had to be a budget issue, but I'm still pretty sure they could've at least gave the illusion it was more (like a few cuts to people around the world getting emails, a wider national diversity among Depp's followers, etc.). Or, if it was only supposed to be 100 folks from the nearby region, put the whole F.B.I. factor to use by claiming "government cover-up".
Fourth: Yeah, the whole "we don't fucking know how internet connections work" has no excuse for a movie ALL ABOUT the Internet, or at least how they think the Internet leads to transcendence.
Fifth: Yeah, the whole "we think that the Internet has connection to EVERYTHING electronic, and if the Internet shut down, so would ALL our sources of electricity" thing is even stupider than the "not knowing how Internet connections work" thing. Oh, and even worse, both Cyber-Depp and his wife are actually implied to have SURVIVED the global blackout, with their electronic souls preserved in the "Faraday cage", and are heavily implied to have a second-shot at making the "Transcendence" actually work - an ending that, frankly, makes the movie even MORE B.S. than it already was.
So, yeah, that's "Transcendence": a movie that tries to act smart, but winds up acting SO dumb, it's attempts at ambiguity makes it look like a technophobic, neo-Luddite nightmare. And if "Jupiter Ascending" and "Lucy" are anything to go by, we're only to get even MORE extra-dumb sci-fi films trying to be extra-smart this year (hopefully the redeeming difference is that they're going straight to the action, instead of trying to give philosophical lectures on technology that are either written idiotic, or handled so clumsily they end up idiotic).
Oh, and if you DO want to see a pseudo-science fiction, pseudo-philosophical film that WAS doing it's homework, "Goodbye World" certainly looked like it knew what it was doing with its "apocalypse survival" story. Just saying.