Difficult. I'm torn between Rapture, Columbia or Neo Paris from Remember Me.
If I consider all of them in their original optimal environments (paid oxygen in Rapture but no crazy splicers, racism in Columbia but no violent uprising, slums and 'memory poverty' in Neo Paris but no leapers) then I think Columbia would win by a hair simply for being up in the sky and able to move anywhere. If I could have my own floating, flyable house then it'd be awesome. Next would be Neo Paris in a non-slum area and then Rapture.
I considered other cities (Dunwall, Insert Name Here from almost any Final Fantasy, Firenze, GTA cities) but the plagues, racism, unsanitary conditions and/or general unrest and crime disqualified them.
If I consider all of them in their original optimal environments (paid oxygen in Rapture but no crazy splicers, racism in Columbia but no violent uprising, slums and 'memory poverty' in Neo Paris but no leapers) then I think Columbia would win by a hair simply for being up in the sky and able to move anywhere. If I could have my own floating, flyable house then it'd be awesome. Next would be Neo Paris in a non-slum area and then Rapture.
I considered other cities (Dunwall, Insert Name Here from almost any Final Fantasy, Firenze, GTA cities) but the plagues, racism, unsanitary conditions and/or general unrest and crime disqualified them.