Generally, any game that sucks in general tends to make friends into enemies. That terrible fire warrior shooter for the PS2 (It centered around the Tau and still managed to suck! TAU!) and that sequel to Bomberman 64 (So disappointing...). However, for games seemingly engineered around making people despise you, I'd have to agree with some of the above posters: Any competetive party game (Mario party, Worms, etc.) tends to ignite tempers.
@Kaisharga: Someone who actually enjoys playing as the Arbiter? Thought I was the only one in the country.