That reminds me of a few moments in MGS4, most notably Psycho Mantis.
That was a fun little moment
And I find it funny when games do this. Sure it breaks immersion for some people, but I find it a welcome change from the "grim, gritty, and super-serious" tones most games try, and fail at setting.
I read in a preview for Marvel vs. Capcom 3 that Deadpool will constantly break the 4th wall. One example was he takes his own health bar and beats the opponent with it. It will be interesting to play with him when the game comes out.