MMOs in general. When I was a kid reading PC Gamer, Ultima Online sounded incredible. I'd fantasize about it. I forced my computer to run EQ when Ruins of Kunark came out (had to turn off the damn sky to get an almost playable frame rate), and was all about AO and so on. Now I can only bring myself to screw around in GW2 once in a while, occasionally play Rift a bit, and that's it. Just hate them. Wish there was an MMO that didn't devolve into "kill tough monsters for better loot to kill tougher monsters" treadmill, or at least did it with some panache, like Monster Hunter.
Forgotten Realms. I guess I don't exactly hate it, but as I've explored other fantasy novels and stuff, it's become more and more stale. Some books can be really good and refreshing, but it's not often. Same with DragonLance. And damn, am I tired of beautiful white people saving the day (which is actually killing me with A Song of Ice and Fire and Wheel of Time, even though I still enjoy both).
Final Fantasy. I still love and froth at the mouth over FF6 (and adopted a stray cat that I've named Sabin), but FFX was the last one I could bring myself to finish; couldn't bring myself to try the sequels because I hate Yuna, I don't care much for Rikku, and don't care to meet Payne. FF12 wasn't as bad as I first thought, but it didn't hold my interest. FF13 was a crime against taste and decency.
Journalism. Maybe I was naive, but in high school, journalism seemed so bad ass and courageous. Now that I've peeled back some layers and seen the progression of both print and televised journalism, I'm sick of it. I still keep up with news, but I have to comb through shit to find something I find trustworthy.
Star Wars. I still love the original trilogy. And I love KotoR 1 and 2. But man, soon that cow ain't gonna have much milk left.
Dogs. I love animals, but cats are so much quieter and easier to deal with. And even though they might climb curtains and stuff, I've never had a cat eviscerate my things the way my dogs used to.
CAPCHA: Cupid's arrow. And yes, obligatory joke about ex-girlfriends here. Though I do miss my former fiancee.