You know, the number of bugs in Brotherhood has got me thinking that maybe a yearly release cycle isn't as good for the series as Ubisoft say it is. I've fallen through the river, been locked out of the Animus, had assassination target scripts not trigger properly, causing desynchronization because they died "too early", gotten stuck in the geometry, and the list goes on and on. That's not even counting some of the 100% synch failures caused by me doing exactly what the requirements were (I'm looking at you, "Calling all Stand-Ins"; you told me to kill them using recruits, I called the recruits in, the target dies by the recruit's hand, and bam, 100% synch failure O_O).
I love the game, but damn it's infuriating seeing how little they cared about making it all work properly. I'm afraid Revelations will turn out to be similarly tarnished.
They need to slow down and actually do some bugfixing instead of pushing it out the door.
I'll add my own speculation for the new time and place: 17th and 18th Century Europe, possibly France or England. You've got Oliver Cromwell, Louis XIV, the Enlightenment, The Glorious Revolution, the London fire, a plague outbreak, and a whole bunch of scheming, conspiracy, betrayals, assassinations, and other assorted corruption. Was just as pivotal and turbulent a time for the history of Western civilization as the Renaissance.