V.A.T.S Hit 'em in the...

[Dirty Hipsters]

I go for the head, unless I'm out too far for VATS to hit with a greater than 50% chance, in which case I just iron sight it and go for the head myself. Thankfully since I'm pretty decent at shooters I can almost always pull off the headshot without needing to rely on VATS.

 

[Moonlight Butterfly]

I hit guys in the head, animals and Deathclaws in the legs, Insects in the antenna and if mutants have large weapon *snort* I shoot it out of their hands before going for the legs.

Seems to work okay. Stealth and a sniper rifle are things I use most.

 

[FalloutJack]

Funny thing about VATS. I like to go for alot of things, dependent on who or what it is and how vulnerable it might be. Check this out.

Radscorpions - The tails.
Most humanoid targets - The heads.
Cazadors - Doesn't matter. They've got low armor.
Things on four legs - The heads, but that's because the torso is BEHIND the head.
Giant Mantids - ***

The funny thing about the New Vegas mantis is that there's a funny glitch to it. The right claw - or the left - does this thing where it'll be at 95% rate to hit at a distance while the rest are lower. You shoot it and the mantis explodes. It's funny.

 

[Ice Car]

Always the head if it has a reasonable accuracy. In my current file though it's almost always 95% at most ranges with any gun that doesn't have crappy spread. I have various perks that increase accuracy in VATS.

 

[Wickatricka]

I don't really use vats, to me its seems like a cop out like you cant aim yourself.

 

[bootz]

I aim for the right claw

 

[Altorin]

always the head. if you shoot anything else without a definite reasn (like getting them to drop a particularly nasty weapon, like a heavy weapon) then it's always head.

 

[Myrl]

I'm just going to quote some random guy I met. "If it's not in the head, you're wasting ammo."

 

[Souplex]

I aim for the legs. Reasonably high chance to hit, and makes em easier to run down in melee.

 

[The Artificially Prolonged]

In the groin with a turbo plasma rifle, never gets old. That's what I missed in the newer Fallouts, they needed more crotch shoots...er no I don't mean like that >.>

 

[haaxist]

Always the head...unless it's got no chance of hitting, then it's a bullet to the gut.

Basically... This. Unless they`re really hurting me, then I might shoot their weapon. XD

 

[phantasmalWordsmith]

I play a sniper based character so I like shooting the head. If I can hit the head (50%+) then I'll aim for the head, if not then I'll adjust to get a better shot or if I'm desperate I'll take out the legs on a melee character or I'll aim for the torso.

 

[kouriichi]

I hit em where it hits.
If i have a 70% chance at the chest, and 20% at the head, im putting a few rounds in his center of mass.

So my answer, where ever i have the highest percentage.

 

[DannyJBeckett]

In Fallout 3:

Humans: Head
Super Mutants: Arms, because it'll make their aim even worse
Super Mutant Behemoths: OH GOD SHOOT! JUST SHOOT IT!
Centaurs: Head and tongues
Radscorpions: Stinger or legs
Deathclaws: Legs
Ghouls: Head, same as humans
Sentrybots: Head or the arm that shoots missiles
Mr. Gutsys: Eye-stalks
Robobrains: erm.. Brains
Protectrons: Head
Mirelurks: The face, if you can. If not, the legs
Mirelurk Kings: Head
Ants: Antennae & head
Yao Guai: Head or forelegs
Dogs: Head
Brahmin: Heads
Mole Rats: Head
Bloatflies & Radroaches: Anywhere!

Extra creatures in New Vegas:

Cazadores: See behemoth description
Coyotes: Head, same as dogs
Geckos: Head
Night Stalkers: Head
Spore Plants: Anywhere
Bighorners: Head
Giant Rats: Anywhere