Fallout 3? I went for a mid-long range small guns specialist, I used mainly my chinese assault rifle, backed up with grenades. Then I got to the end of the game, and also did a few add-on campaigns, and instantly switched to owning squishy ghoul faces with giant burning green balls of plasma and magnetized microfusion cells from the gauss rifle, which might as well be called the 'Grenade sniper rifle'.
As for my character, I planned to play him neutral, but ended up good anyway, given that I felt a bit guilty about the idea of murdering people for pocket change. My tag skills were small guns, repair, and medicine, a nice and healthy balance for a character that might be handy for longer expeditions, and it came off rather well.
Also, he was the most stylish character ever, combat armor and a shady hat. The peak of post-apocalyptic fashion.
Also a bit of a loose canon. I find paradise falls, learn it's a slaver base, and instantly slaughter anyone who takes up arms against me, cutting them in two with a spray from my machine gun.