My final attack? Syringe full of absurdly fast-acting sedative. I then drag him into a room covered in plastic, tape him to a table, make a glass slide of a drop of his blood as a trophy, stab him in the heart, cut him into tiny pieces, and drop the pieces into the nearest body of water.
Alternatively, I'd zap him with a Freeze Ray (not an Ice Beam!), sing a kick-ass villain song, then kill him to death with a Death Ray.
An unfortunate side effect of watching every show I can is that I have no imagination anymore; it's been completely replaced by pop-culture references. I say it's worth it.