Deus Ex + Morrowind = Yes, please.
A tale of intrigue, conspiracy, and prophecy that plays out against the backdrop of proper cyberpunk metropolis that takes up enough real estate to qualify as an island nation. It begins with seemingly random acts of terror carried out by the mysterious Sleeper Cult, which is later revealed to be made up of normal citizens who have had their cybernetic brains/exocortexes remotely hacked. There is a pattern to the attacks, which succeeds in introducing renegade code into the Tribunal computer system, wreaking havoc with the trinity of advanced A.I's that govern the region.
The player assumes the role of a convict whose sentence was purchased by a multinational corporation. Initially, it seems the agent is intended only to gather information about the ongoing terrorism and the chaos within the Tribunal, but as the plot progresses it seems that the Empire Corporation is interested in taking control.
A section of the late game would focus on a hacking operation, hoping to gather information from beyond the Ghost Gate, a system of firewalls and security measures the Tribunal uses to secure their most sensitive information. This reveals one of the darkest secrets: The Tribunal were originally merely an operating system for an advanced piece of hardware, the control cluster for which had to be caged behind the Ghost Gate once it gained self awareness. Couple this with a trip to the geothermal power plant responsible for keeping the Dagoth.UR hardware running. Does the player opt to take over control of the flow of information, reveal the Tribunal's sinister eugenics program (of which the player's character is a product, a clone of one of the original architects of the Tribunal and Dagoth.UR frameworks), or shut down the geothermal vents and return control to the free people?
Naturally, augmentations would abound for the player. They could join various guilds, working as hackers, bodyguards, and spies. They could form alliances with the Great Houses, which would be the disembodied A.I constructs of the directors of the largest interests within the territory. Skills would improve with use, and with augmentation. Shooting a gun enough times makes the user better at it, but getting some top of the line arm software and a long range vision package really ups the effectiveness. Their cognitive functions would become infected with a piece of the renegade code, but instead of merely becoming a platform for Dagoth.UR's software, as others have, the player is able to hack their own brain and use the modified data signature as a way of tricking their way past Dagoth.UR's countermeasures.
In place of Enchantments and Spells, players would be able to create their own code/viruses/applications to use within the game. Such use would include, but not be limited to, remote enemy control, mass shutdowns, medicine ware for the worst virus infections, instant transfer protocols to any previously visited network nodes, as well as cloning functions which act as extra lives for the player's consciousness during the more harrowing information runs.