Eh. I had a friend who was driving me bananas with 'positive' 'motivational' sloguns.
Those were especially annoying because many of them amounted to 'your life would be so much better if you just think positive thoughts'.
That gets on my nerves, so I eventually unfollowed her.
Other things are people PM'ing you lewd suggestive crap constantly. or trying to start some cybersex thing every other day, and basically not listening when I say no to that.
Or, asking me to be their girlfriend even though I barely know this person, what they've said to me so far has mostly just been annoying, and...
Well, if you ask me to be your girlfriend 100 times, and I say no every time, what is it hmm?
You think I'm playing some game or something?
Then again, it's the same attitude I've run into sometimes in real life as well.
No or some kind of resistance seems to be viewed as a challenge. Some kind of game to play, which you'll win if you just keep pestering someone enough. Because obviously they didn't really mean it, and totally DO want you actually, really...
Ugh. Sorry. XD
(is that last one something only girls get? I dunno. Feels that way, sometimes, going by the few times I've ever talked to anyone about it.)
Anyway, if it bothers you, unfollow them. If they are a super-pest, unfriend them.
And if they completely cross the line, blocking them may be in order.