Hero in a half shell said:
Maybe Fallout Texas. It would be like a post-apocalypic western! Herding brahmin across the toxic Rio Grande, having settlements built around oil derricks, getting invaded by Mexico, holding out in the Alamo against mad patriotic hillbillies, fighting giant mutated crocodiles in the swamps, (they could be standins for deathclaws!) Awesome.
You'd also have the Nasa headquarters in Houston, which could be used to form the main plotline about the space programme the government had established, and it's exact relation to the vaults.
So, basically no change to how Texas is now, then? That might even make it nicer.
I kid, I love my state. Though, that would be an annoyingly massive game world. The Capitol and New Vegas were all single large metropolitan areas, and Texas kind of lacks a single cohesive one, spreading ours out to far. Austin, Houston, San Antonio, Dallas/Fort Worth, El Paso, Lubbock, each with at least about a hundred miles inbetween. Bit large, really.
I like this idea of New York, New York, though. Yeah, the city is overdone, but the already-destroyed city, with recovering skyline, would be interesting to see, roam about, and get ribboned by deathclaws.